CURRENT RESEARCH FIELD: Short and ultrashort laser-matter interactions; Biointerfaces; Biophotonics.

EXPERTISE AND COMPETENCES:

• Microfabrication of biomimetic interfaces by laser processing,
• Photonic investigations of surfaces at micro- and nanoscale for biomedical applications,
• Design, development and microfluidic testing of lab-on-a-chip glass and polymeric platforms for advanced in vitro testing.

LIST OF 5 SELECTED ARTICLES:

1. Alexandra Bran, Stefana Orobeti, Florin Jipa, Anca Bonciu, Emanuel Axente, Livia E. Sima, Felix Sima, Koji Sugioka, Tissue-like scaffolds created by two photon polymerization for testing cancer cell behavior in confined environments, ACS Applied Bio Materials, 2025, 8(8), pp. 7344-7356.
2. S. Orobeti, L. E. Sima, ... E. Axente, S. Sandel, M. Zamfirescu, I. Tiseanu, F. Sima, First in vitro cell co-culture experiments using laser-induced high energy electron FLASH irradiation – potential for anti-cancer therapeutic strategies, Scientific Reports (2024) 14:14866S.
3. L. Ionel, F. Jipa, A. Bran, E. Axente, G. Popescu-Pelin, F. Sima, K. Sugioka, Effect of varied beam diameter of picosecond laser on Foturan glass volume microprocessing, Optics Express 32, 11, 20109-20118 (2024).
4. C. E. Staicu, F. Jipa, E. Axente, M. Radu, B. M. Radu, F. Sima, Lab-on-a-chip platforms as tools for drug screening in neuropathologies associated with blood brain barrier alterations, Biomolecules (2021), 11, 916.
5. Emanuel Axente, Mihai Sopronyi, Camelia Matei Ghimbeu, Cristina Nita, Aissam Airoudj, Gautier Schrodj and Felix Sima, Matrix-Assisted Pulsed Laser Evaporation: A novel approach to design mesoporous carbon films, Carbon 122 (2017) 484-495.

ResearcherID: C-4812-2011
ORCID: 0000-0003-1946-5863

Full CV

CURRENT RESEARCH FIELD: Biophotonics

EXPERTISE AND COMPETENCES:

• Biomimetic laser processing,
• combinatorial laser processing of organic materials,
• characterisation and testing of photonic structures at micro- and nanoscale for biological applications,
• Development and assembling of lab-on-a-chip glass and polymeric platforms for advanced in vitro testing.

LIST OF 5 SELECTED ARTICLES:

1. Sima F., Sugioka K., Mart?006e0065z V?007a0071uez R., Osellame R., Kelemen L., Ormos P.,Three-dimensional femtosecond laser processing for lab-on-a-chip applications Nanophotonics,7 (3), 613, 2018;
2. Sima F., Xu J., Wu D., Sugioka K.,Ultrafast Laser Fabrication of Functional Biochips: New Avenues for Exploring 3D Micro-and Nano-Environments, Review, Micromachines 8 (2), 40, 2017;
3. Axente E., Sopronyi M., Ghimbeu CM, Nita C., Airoudj A., Schrodj G., Sima F., Matrix-Assisted Pulsed Laser Evaporation: A novel approach to design mesoporous carbon films, , Carbon 122, 484, 2017;
4. Sima F., Davidson PM, Dentzer J, Gadiou R, Pauthe E, Gallet O, Mihailescu IN, Anselme K, Inorganic-organic thin implant coatings deposited by lasers, ACS Applied Materials & Interfaces, 7(1):911, 2015;
5. Sima F., Axente E., Sima L.E., Tuyel U., Eroglu M.S., Serban N., Ristoscu C., Petrescu S.M., Toksoy Oner E., Mihailescu I.N., "Combinatorial Matrix-Assisted Pulsed Laser Evaporation: single-step synthesis of biopolymer compositional gradient thin film assemblies", Applied Physics Letters,101, 233705, 2012.

ResearcherID: C-2734-2011
ORCID: 0000-0001-5911-0288

Full CV

CURRENT RESEARCH FIELD: Laser micro- and nano-processing, integrated optics, photonic micro and nanodevices

EXPERTISE AND COMPETENCES:

Design, construction and exploitation of ultrafast laser processing platforms for:

• Laser Direct-Writing (LDW);
• Two-Photon Photopolymerization (TPP) for 3D laser lithography;
• Laser Induced Forward Transfer (LIFT);
• Waveguides in transparent bulk materials;
• Development of new laser methods for fast structuring of large-area with resolution below the diffraction limit;
• Characterization techniques based on pump-probe scheme with sub-picosecond resolution.

LIST OF 5 SELECTED ARTICLES:

1. Marian Zamfirescu, Adrian Dinescu, Mihai Danila, Gabriel Socol, Catalina Radu, "The role of the substrate material type in formation of laser induced periodical surface structures on ZnO thin films", App. Surf. Science 258 (23) 9385-9388 (2012).
2. C. Mauclair, M. Zamfirescu, J. P. Colombier, G. Cheng, K. Mishchik, E. Audouard, and R. Stoian, "Control of ultrafast laser-induced bulk nanogratings in fused silica via pulse time envelopes", Opt. Express 20 (12) 12997-13005 (2012).
3. Florin Jipa, Adrian Dinescu, Mihaela Filipescu, Iulia Anghel, Marian Zamfirescu, and Razvan Dabu, "Laser parallel nanofabrication by single femtosecond pulse near-field ablation using photoresist masks", Opt. Express 22 (3) 3356-3361 (2014).

ResearcherID: G-3266-2011
ORCID: 0000-0003-1143-4376

Full CV

CURRENT RESEARCH FIELD: Optical metrology, UV-VIS and THz spectroscopy

EXPERTISE AND COMPETENCES:

• Calibration, validation, and characterization of spectroradiometers and spectrometers (partner in Horizon Europe programme agreement no. 101086287, RemoTrees)
• Development of portable, stable calibration reference devices for field applications (coordinator in project type PED- PED470)
• Uncertainty propagation and analysis for vegetation monitoring sensors (COST Actions - WP leader: SENSECO, PANGEOS)
• Research on luminescent and sensitive materials for ionizing radiation detection using UV-VIS spectroscopy
• Characterisation of materials properties in UV-IR, THz range (partner in project type PCCDI - SENSIS)

LIST OF 5 SELECTED ARTICLES:

1. Stancalie, Andrei, Flavio Esposito, Razvan Mihalcea, Laura Mihai, Daniel Ighigeanu, Anubhav Srivastava, Stefania Campopiano, and Agostino Iadicicco. "Electron radiation impact on Long Period Gratings in different optical fibers." IEEE Sensors Journal (2024).
2. Werfeli, Mike, Andreas Hueni, Dessislava Ganeva, Giulia Ghielmetti, and Laura Mihai. "Uncertainty budget for a traceable operational radiometric calibration of field spectroradiometers, calibration of the heliosphere." IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing 17 (2023): 400-410.
3. Bleotu, Petri?or Gabriel, Laura Mihai, Dan Sporea, Adelina Sporea, Mihai Straticiuc, and Ion Burducea. "Impact of 3MeV Energy Proton Particles on Mid-IR QCLs." Nanomaterials 13, no. 4 (2023): 677.
4. Mihai, Laura, Razvan Mihalcea, Roxana Tomescu, Costel Paun, and Dana Cristea. "Selective Mid-IR metamaterial-based gas sensor system: Proof of concept and performances tests." Nanomaterials 12, no. 6 (2022): 1009.
5. Pacheco-Labrador, Javier, Andreas Hueni, Laura Mihai, Karolina Sakowska, Tommaso Julitta, Joel Kuusk, Dan Sporea et al. "Sun-induced chlorophyll fluorescence I: Instrumental considerations for proximal spectroradiometers." Remote Sensing 11, no. 8 (2019): 960.
6. Mihai, Laura, Alasdair Mac Arthur, Andreas Hueni, Iain Robinson, and Dan Sporea. "Optimized spectrometers characterization procedure for near ground support of esa flex observations: Part 1 spectral calibration and characterisation." Remote Sensing 10, no. 2 (2018): 289.

ResearcherID: S-2383-2016
ORCID: 0000-0003-3869-1890

Full CV

CURRENT RESEARCH FIELD: Optics & Photonics

EXPERTISE AND COMPETENCES:

• Optical fiber technologies: design, fabrication, and characterization
• Optical fiber sensors for environmental, biological and ionizing radiation monitoring
• Radiation effects on optical fibers and dopants (ionizing radiation-induced degradation and performance analysis)
• Development and application of fiber-based sensing systems for temperature, humidity, and ionizing radiation detection
• Interaction of radiation with photonic materials and sensor systems
• Nonlinear effects in optical fibers and their impact on sensor performance
• Experimental techniques for optical characterization under harsh environments
• Laser induced breakdown spectroscopy

LIST OF 5 SELECTED ARTICLES:

1. Andrei Stancalie, Flavio Esposito, Razvan Mihalcea, Laura Mihai, Daniel Ighigeanu, Anubhav Srivastava, Stefania Campopiano, Agostino Iadicicco, Electron Radiation Impact on Long Period Gratings in Different Optical Fibers, IEEE SENSORS JOURNAL 25 (2) 2806–2813 (2025) https://doi.org/10.1109/JSEN.2024.3508885
2. Andrei. Stancalie, Ionut Relu Andrei, Mihai Boni, Angela Staicu, Mihail Lucian Pascu, Droplet temperature measurement using a fiber Bragg grating, Applied Thermal Engineering 254, 123905 (2024) https://doi.org/10.1016/j.applthermaleng.2024.123905
3. Andrei Stancalie, Flavio Esposito, Constantin Daniel Negu?, Marian Ghena, Razvan Mihalcea, Anubhav Srivastava, Stefania Campopiano, Agostino Iadicicco, „A New Setup for Real-Time Investigations of Optical Fiber Sensors Subjected to Gamma-Rays: Case Study on Long Period Gratings”, Sensors, 20(15), 4129; (2020) https://doi.org/10.3390/s20113017
4. Andrei Stancalie et al., "Long Period Gratings in unconventional fibers for possible use as radiation dosimeter in high-dose applications", SENSORS AND ACTUATORS A-PHYSICAL  Volume: 271, Pages: 223-229, (2018). https://doi.org/10.1016/j.sna.2018.01.034
5. Andrei. Stancalie et al., "Arc-induced Long Period Gratings in standard and speciality optical fibers under mixed neutron-gamma irradiation", SCIENTIFIC REPORTS, Volume 7, Article Number 15845, (2017). https://doi.org/10.1038/s41598-017-16225-4

ResearcherID: M-9267-2018
ORCID: 0000-0003-2041-4924

Full CV

CURRENT RESEARCH FIELD: Lasers science

EXPERTISE AND COMPETENCES:

- Lasers material processing 

- Development of optical experimental setups

- Microfluidic devices manufacturing

LIST OF 5 SELECTED ARTICLES:

Jipa, F; Ionel, L; Zamfirescu, M; „ Advances in Design and Fabrication of Micro-Structured Solid Targets for High-Power Laser-Matter Interaction” PHOTONICS  11, (11), 1008, (2024)

Ionel, L; Jipa, F; Bran, A; Axente, E; Popescu-Pelin, G; Sima, F; Sugioka, K; "Effect of varied beam diameter of picosecond laser on Foturan glass volume microprocessing," OPT. EXPRESS 32, 20109-20118 (2024)

Croitoru, G; Jipa, F; Greculeasa, M; Broasca, A; Voicu, F; Gheorghe, L; Pavel, N; "Buried Depressed-Cladding Waveguides Inscribed in Nd3+ and Yb3+ Doped CLNGG Laser Crystals by Picosecond-Laser Beam Writing"; MATERIALS 17 (8) 1758 (2024)

Croitoru, G; Jipa, F; Pavel, N; "Laser emission from buried depressed-cladding waveguides inscribed in Nd: YAG ceramics by picosecond-laser beam writing"; OPTICAL MATERIALS 148, 114772 (2024).

Orobeti, S; Sima, L. E. ; Porosnicu, I;  Diplasu, C;  Giubega, G; Cojocaru, G;  Ungureanu, R;  Dobrea, C; Serbanescu,  M;  Mihalcea, A; Stancu, E; Staicu, C. E;  Jipa, F; Bran, A; Axente, E;  Sandel, S;  Zamfirescu, M; Tiseanu,  I; Sima, F; "First in vitro cell co?culture experiments using laser?induced high?energy electron FLASH irradiation for the development of anti?cancer therapeutic strategies" SCIENTIFIC REPORTS, 14:14866, (2024) 

ResearcherID: P-3376-2014
ORCID: 0009-0000-2528-8942

Full CV

CURRENT RESEARCH FIELD: Material Science

EXPERTISE AND COMPETENCES:

• Synthesis of carbon materials and metallic/metal oxide nanoparticles by chemical methods;
• Physico-chemical characterization (N₂ and CO₂ Adsorption, Raman spectroscopy, termogravimetry measurements, atomic absorption spectrophotometry;
• Electrochemical characterization (Li-ion and Na-ion batteries).

LIST OF 5 SELECTED ARTICLES:

1. 1.  Hard carbon derived from coconut shells, walnut shells, and corn silk biomass waste exhibiting high capacity for Na-ion batteries; C. Nita, B. Zhang; J. Dentzer; C. Matei Ghimbeu; Journal of Energy Chemistry 58 (2021) 207-218, IF (2021): IF (2021): 13.599; AIS (2021): 1.525. Doi: 10.1016/j.jechem.2020.08.065.

   2. Link between Alkali Metals in Salt Templates and in Electrolytes for Improved Carbon-Based Electrochemical Capacitors; A. Platek, C. Nita, C. Matei Ghimbeu, E. Frackowiak, K. Fic; ACS Applied Materials & Interfaces 13 (2021) 2584-2599, IF (2021): 10.383; AIS (2021): 1.608. Doi: 10.1021/acsami.0c18627.

   3. Eco-friendly synthesis of SiO₂ nanoparticles confined in hard carbon: an intriguing material for Li-ion batteries; C. Nita, J. Fullenwarth, L. Monconduit, J.-M. Le Meins, P. Fioux, J. Parmentier, C. Matei Ghimbeu; Carbon 143 (2019) 598-609, IF (2019): 8.821; AIS (2019): 1.398. Doi: 10.1016/j.carbon.2018.11.069.

   4. Influence of carbon characteristics on Sb/carbon nanocomposites formation and performances in Na-ion batteries; C. Nita, J. Fullenwarth, L. Monconduit, L. Vidal, C. Matei Ghimbeu; Materials Today Energy 13 (2019) 221-232; IF (2019): 5.604; Doi: 10.1016/j.mtener.2019.05.009.

   5. Understanding the main factors affecting the performances of carbon/Sn based nanocomposites in Li-ion batteries; C. Nita, J. Fullenwarth, L. Monconduit, J. Parmentier, J.-M. Le Meins, M. Sougrati, C. Matei Ghimbeu; ChemElectroChem, 5 (2018) 3249-3257, IF (2018): 3.975; AIS (2018): 0.840. Doi: 10.1002/celc.201800835.

Full CV

CURRENT RESEARCH FIELD: - Biocompatibility tests on laser processed materials. - Cell investigation on microfluidic devices.

EXPERTISE AND COMPETENCES:

• Mesenchymal stem cells and osteoblasts culture.
• Analysis of cytotoxic potential of biomaterials using MTS assay.
• Analysis of cell adhesion supported by fluorescence microscopy.
• Annealing and chemical etching treatment on Foturan photosensitive glass.

LIST OF 5 SELECTED ARTICLES:

Full CV

CURRENT RESEARCH FIELD: Biophotonics, Laser Microprocessing

EXPERTISE AND COMPETENCES:

• two photon polymerization of polymeric scaffolds
• laser micro and nanofabrication for Lab-on-Chip platforms
• time-lapse microscopy for cell motility evaluation
• fluorescence microscopy of adherent cells

LIST OF 5 SELECTED ARTICLES:

1. Bran A., Jipa F., Orobeti S., Axente E., Sima L.E., Sima F., Sugioka K. Polymeric scaffolds fabricated by two photon polymerization for 3D cancer cell invasion assay, Proc. SPIE 12873, Laser-based Micro- and Nanoprocessing XVIII, 128730B (2024);
   
2. Sima L., Tudor M., Orobeti S., Filimon A., Negroiu G., Munteanu C., Chiritoiu G., Roseanu A., Florian P., Icriverzi M., Porosnicu I., Avram D., Bran A., Simion S., Tiseanu I., Sima F.; Ultra-High Dose Rate Ionizing Radiation for FLASH Radiotherapy Applications, Ionizing Radiation - Insights into Chemistry, Biology, and Applications. IntechOpen; 2025,
   
3. Orobeti, S., Dinca, I., Bran, A., Tiseanu, I., Sima, F., Petrescu, S. M. and Sima, L. E.. Streamlined Quantification of p-?-H2AX Foci for DNA Damage Analysis in Melanoma and Melanocyte Co-cultures Exposed to FLASH Irradiation Using Automated Image Cytometry. Bio-protocol 15(4): e5208. (2025) DOI: 10.21769/BioProtoc.5208.
4. Ionel L., Jipa F., Bran A., Axente E., Popescu-Pelin G., Sima F., and Sugioka K., Effect of varied beam diameter of picosecond laser on Foturan glass volume microprocessing, Opt. Express 32, 20109-20118 (2024)
5. Orobeti, S., Sima, L. E., Porosnicu, I., Diplasu, C., Giubega, G., Cojocaru, G., Ungureanu, R., Dobrea, C., Serbanescu, M., Mihalcea, A., Stancu, E., Staicu, C. E., Jipa, F., Bran, A., Axente, E., Sandel, S., Zamfirescu, M., Tiseanu, I., & Sima, F. First in vitro cell co-culture experiments using laser-induced high energy electron FLASH irradiation for the development of anti-cancer therapeutic strategies. Sci Rep 14, 14866 (2024).
   

ResearcherID: H-5788-20
ORCID: 0009-0000-4957-4724

Full CV

CURRENT RESEARCH FIELD: Optics & Photonics 3D Design and Mechanics

EXPERTISE AND COMPETENCES:

• Optical fiber technologies: design, fabrication, and characterization
• Optical fiber sensors for environmental, biological and ionizing radiation monitoring
• Radiation effects on optical fibers and dopants (ionizing radiation-induced degradation and performance analysis)
• Development and application of fiber-based sensing systems for temperature, humidity, and ionizing radiation detection
• Interaction of radiation with photonic materials and sensor systems
• Nonlinear effects in optical fibers and their impact on sensor performance
• Experimental techniques for optical characterization under harsh environments
• Vibration and shocks - testing of components for space applications
• Spectroradiometry investigations - development of experimental setups, characterization of diffuse reflectance and emissivity.

LIST OF 5 SELECTED ARTICLES:

1. A. Stancalie et al., „Electron radiation impact on Long Period Gratings in different optical fibers”, IEEE Sens J, 2024, doi: 10.1109/JSEN.2024.3508885.
2. F. Esposito et al., “Optical properties of thin films monitored in real-time at high gamma radiation doses using long period fiber gratings,” Opt Laser Technol, vol. 176, p. 111019, Sep. 2024, doi: 10.1016/J.OPTLASTEC.2024.111019.
3. F. Esposito et al., “The Impact of Gamma Irradiation on Optical Fibers Identified Using Long Period Gratings,” Journal of Lightwave Technology, vol. 41, no. 13, pp. 4389–4396, Jul. 2023, doi: 10.1109/JLT.2022.3191163.
4. A. Stancalie et al., “A New Setup for Real-Time Investigations of Optical Fiber Sensors Subjected to Gamma-Rays: Case Study on Long Period Gratings,” Sensors 2020, Vol. 20, Page 4129, vol. 20, no. 15, p. 4129, Jul. 2020, doi: 10.3390/S20154129.
5. R. Mihalcea, D. Ighigeanu, D. Negut, and A. Stancalie, “COMPARATIVE EVALUATION OF ELECTRON AND GAMMA INDUCED EFFECTS ON FBG FABRICATED IN STANDARD AND RADIATION HARDENED OPTICAL FIBERS BY DIFFERENT TECHNIQUES,” U.P.B. Sci. Bull., Series A, vol. 85, no. 3, p. 2023
6. Mihai, L; Mihalcea, R; Tomescu, R; Paun, C; Cristea, D; "Selective Mid-IR Metamaterial-Based Gas Sensor System: Proof of Concept and Performances Tests"; NANOMATERIALS MAR (2022).

ResearcherID: D-2100-20
ORCID: 0000-0002-5308-3570

Full CV

CURRENT RESEARCH FIELD: Cell Biology, Biophysics, Neurobiology

EXPERTISE AND COMPETENCES:

• Analysis of endothelial cell functions in the blood-brain barrier under physiological and pathological conditions using lab-on-chip and microfluidic platforms.

• Application of lab-on-a-chip systems for evaluating radiosensitivity and radioresistance in cancer cells during radiotherapy.

• Integration of microfluidics with cell biology and biophysics for advanced in vitro disease modeling and therapeutic testing.

LIST OF 5 SELECTED ARTICLES:

• Staicu E. C., Jipa F., Axente E., Radu M., Radu B. M., Sima F. – Lab-on-a-Chip Platforms as Tools for Drug Screening in Neuropathologies Associated with Blood–Brain Barrier Alterations

• Staicu C. E., Jipa F., Porosnicu I., Bran A., Stancu E., Dobrea C., Radu B. M., Axente E., Tiseanu I., Sima F., Sugioka K. – Glass Lab-on-a-Chip Platform Fabricated by Picosecond Laser for Testing Tumor Cells Exposed to X-ray Radiation

• Orobeti S., Sima L. E., Porosnicu I., Diplasu C., Giubega G., Cojocaru G., Ungureanu R., Dobrea C., Serbanescu M., Mihalcea A., Stancu E., Staicu C. E., Jipa F., Bran A., Axente E., Sandel S., Zamfirescu M., Tiseanu I., Sima F. – First In Vitro Cell Co-Culture Experiments Using Laser-Induced High-Energy Electron FLASH Irradiation for the Development of Anti-Cancer Therapeutic Strategies

• Stoica R., Rusu C. M., Staicu E. C., Burlacu A. E., Radu M., Radu B. M. – Ca2+ Homeostasis in Brain Microvascular Endothelial Cells
  

• Staicu E. C., Predescu D. V., Rusu C. M., Radu B. M., Cretoiu D., Suciu N., Cretoiu S.M., Voinea, S. C. – Role of microRNAs as Clinical Cancer Biomarkers for Ovarian Cancer: A Short Overview

CURRENT RESEARCH FIELD: Micro/Nano Photonic Devices

EXPERTISE AND COMPETENCES:

• development of laser methods for high resolution processing of materials;

• laser fabrication and optical characterization of photonic devices and integrated optics;

LIST OF 5 SELECTED ARTICLES:

Full CV

CURRENT RESEARCH FIELD: Optical Metrology

EXPERTISE AND COMPETENCES:

LIST OF 5 SELECTED ARTICLES: